Cheri Blauwet is an American wheelchair racer and has competed at the Olympic and Paralympic level.  At the 2004 Olympic Games, she finished 5th in the demonstration sport of Women's 800m wheelchair. She also participated in the 2004 Summer Paralympics, where she won gold in the 800 m, bronze in the 5000 m, and another bronze in the marathon.

Lance Briggs is a former NFL linebacker. As a former college football player at the University of Arizona, he was drafted by the Chicago Bears in the third round of the 2003 NFL Draft, where he played his entire 12-year career.

Bruckheimer is an American film and television producer. He has been active in the genres of action, drama, fantasy and science fiction. His best known television series are “CSI: Crime Scene Investigation,” while some of his best-known films include “Pirates of the Caribbean,” “Black Hawk Down,” “Pearl Harbor,” “Flashdance,” “Top Gun,” and much more.

Bruschi is a former football player for the University of Arizona and two-time consensus All-American. He was drafted by the New England Patriots in the third round of the 1996 NFL Draft, and played his entire 13-season, professional career with the Patriots. Bruschi won three Super Bowls and was a two-time All-Pro selection.

Budinger is a former basketball player for the University of Arizona. He was first drafted in 2009 by the Houston Rockets.

Kurt Busch is professional stock car racing driver. He won the NASCAR Cup Series championship in 2004. With a 2006 win in the Busch Series, Busch became one of only 29 drivers to win races in all three of NASCAR's top divisions: the Cup Series, the Xfinity Series, and the Camping World Truck Series. Busch is also a Daytona 500 winner, accomplishing the feat in 2017.

Ka'Deem Carey is a former University of Arizona football player.  He was drafted by the Chicago Bears in the fourth round of the 2014 NFL draft.

Richard Carmona is an American physician, police officer, public health administrator, and politician. He was a vice admiral in the Public Health Service Commissioned Corps and served as the 17th Surgeon General of the United States.

Antoine Cason played college football for the University of Arizona, where he was recognized as an All-American and won the Jim Thorpe Award. He was drafted by the San Diego Chargers in the first round of the 2008 NFL Draft. He has also played for the Arizona Cardinals.

Raul H. Castro was a Mexican-born American politician. He has served in both elected and non-elected public offices, including United States Ambassador and the 14th governor of Arizona (1975–77). He was the first Mexican American to be elected governor of Arizona.

Chuck Cecil was a walk-on at the University of Arizona, eventually earning consensus All-America and Pacific-10 Conference Defensive Player of the Year honors after his nine-interception senior season in 1987. He held the Pac-10 record for career interceptions, with 21 (Lamont Thompson later broke the mark with 24), and set the Wildcats' school single-game record (and tied the Pac-10 record) with four interceptions against Stanford in 1987.
He is also a former player and coach in the NFL. He is currently the senior defensive analyst at the University of Arizona. He previously served as a defensive assistant for the Tennessee Titans and Los Angeles Rams. Cecil also spent two seasons (1999–2000) as a television analyst for University of Arizona football games.

Anna Maria Chávez is an attorney, inspirational speaker, writer and community leader. From 2011-16, Chávez served as the chief executive officer of the Girl Scouts of the USA and was the first woman of color to head the organization.